【近五年发表的代表性论文 】

1.         Zhai, S# *.; Zhang, X#.; Jiang, M#.; Liu, Y.; Qu, G.; Cui, X.; Hirschbiegel, C.-M.; Liu, Y.; Alves, C.; Lee, Y.-W.; Jiang, G.; Yan, B*.; Rotello, V. M*., Journal of Hazardous Materials 2024, 466, 133590.2.  

2.         Liu, Y., Wang, N., Li, M, Gao, Z., Zhang, G., Yang, Y., Wei, S., Hao, J., Cui, J., Yu, Q*., Zhai, S*., Chemistry of Materials 2024, 36, 5017-5027

3.         Liu, F.; Zhai, S*.; Gao, D.; Yang, S.; Zhao, B.; Lin Z*., Analytica Chimica Acta 2024, 1305, 342588

4.         Zheng, Y.; Zhai, S. M*; Xiao, M. M.; Dong, P. Z.; Xu, J. R.; Zhao, B. X*., Spectrochimica Acta Part a-Molecular and Biomolecular Spectroscopy 2024, 309, 123822.

5.         Li, F.; Zhai, S. M#.; Xian-Yu, J. J.; Zhao, B. X*.; Lin, Z. M*., Talanta 2024, 271, 125684.

6.         Wang, Q.; Gao, Z.; Zhao, K.; Zhang, P.; Zhong, Q.-Z.; Yu, Q.; Zhai, S*.; Cui, J*., Chinese Chemical Letters 2022, 33 (4), 1917-1922.

7.         Sun, H.; Zhao, Y.; Zhang, P.; Zhai, S.; Li, W.; Cui, J., Nanoscale 2022, 14 (8), 3040-3048.

8.         Zhang, G.; Wang, N.; Sun, H.; Fu, X.; Zhai, S.; Cui, J., Biomaterials Science 2021, 9 (20), 6940-6949.

9.         Zhang, G.; Fu, X.; Sun, H.; Zhang, P.; Zhai, S.; Hao, J.; Cui, J.; Hu, M. ACS Applied Materials & Interfaces 2021, 13 (12), 13978-13989.

10.     Goswami, R.; Jeon, T.; Nagaraj, H.; Zhai, S.; Rotello, V. M., Trends in Pharmacological Sciences 2020, 41 (10), 743-754.

11.     Lee, Y.-W.; Luther, D. C.; Kretzmann, J. A.; Burden, A.; Jeon, T.; Zhai, S.; Rotello, V. M., 2019, 9 (11), 3280-3292.

拟招收学术、专业硕士研究生各一名

• 2002-09-01-2005-12-01
  山东大学
  生物科学类其他专业
• 1999-09-01-2002-07-01
  山东大学
  生物科学类其他专业
• 1995-09-01-1999-07-01
  曲阜师范大学
  生物学教育

• 2018-03 — 2019-04
  马萨诸塞大学阿姆赫斯特分校
• 2008-10 — 2009-10
  美国韦恩州立大学芭芭拉.安Karmanos癌症研究中心
• 2015-10 — Now
  化学与化工学院山东大学
  副教授
• 2009-01 — 2015-09
  化学与化工学院山东大学
  讲师
• 2008-10 — 2009-10
  病理学系美国韦恩州立大学
  访问学者

1. 1.功能化纳米材料的免疫效应分析 2.纳米材料在药物递送中的应用研究 3.化学小分子探针的应用研究

(1)张贵强. Self-adjuvanting photosensitizer nanoparticles for combination photodynamic immunotherapy .BIOMATERIALS SCIENCE .2021 ,9 (20):6940-6949

(2)孙海峰. Transcutaneous delivery of mung bean-derived nanoparticles for amelioration of psoriasis-like skin inflammation .Nanoscale .2022 ,14 (8):3040-3048

(3)岳真名. A ratiometric fluorescent probe based on FRET mechanism for pH and its cell imaging .Dyes and Pigments .2025 ,233

(4)孙吉峻. 抗生素军团告人类战友书 .大学化学 .2024

(5)刘凤亭. A highly sensitive ratiometric fluorescent probe for detecting HSO3？/SO32？ and viscosity change based on FRET/TICT mechanism .ANALYTICA CHIMICA ACTA .2024 ,1305

(6)翟淑梅. Nanoparticles with intermediate hydrophobicity polarize macrophages to plaque-specific Mox phenotype via Nrf2 and HO-1 activation .JOURNAL OF HAZARDOUS MATERIALS .2024 ,466

(7)刘雨嘉. Nanoengineering of Vaccine Nanoparticles via Templating of Metal-Organic Frameworks for Tumor Immunotherapy .Chemistry of Materials .2024 (1520-5002)

(8) NBD-based colorimetric and ratiometric fluorescent probe in NIR for bisulfite .Talanta .2024 ,271

(9)郑一. A novel ratiometric fluorescence probe based on the FRET-ICT mechanism for detecting fluoride ions and viscosity .Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy .2024 ,309

(10)孙海南. The Rational Design and Biological Mechanisms of Nanoradiosensitizers .Nanomaterials .2020 ,10 (3)

(11)Goswami, Ritabrita. Accessing Intracellular Targets throuch Nanocarrier-Mediated Cytosolic Protein Delivery .TRENDS IN PHARMACOLOGICAL SCIENCES .2020 ,41 (10):743

(12)Jia, Jianbo. Susceptibility of Overweight Mice to Liver Injury as a Result of the ZnO Nanoparticle-Enhanced Liver Deposition of Pb²⁺ .Environmental Science & Technology .2017 ,51 (3):1775

(13)Sun, Hainan. Gold Nanoparticle-Induced Cell Death and Potential Applications in Nanomedicine .INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES .2018 ,19 (3)

(14)Lee, Yi-Wei. Protein Delivery into the Cell Cytosol using Non-Viral Nanocarriers .THERANOSTICS .2019 ,9 (11):3280

(15)张秋. P-glycoprotein-evading anti-tumor activity of a novel tubulin and HSP90 dual inhibitor in a .Journal of Pharmacological Sciences .2014 ,126 (1):66

(16)王倩. Co-delivery of enzymes and photosensitizers via metal-phenolic network capsules for enhanced photodynamic therapy .CHINESE CHEMICAL LETTERS .2022 ,33 (4):1917-1922

(17)白雪. Recent Advances in Nanomedicine for the Diagnosis and Therapy of Liver Fibrosis .Nanomaterials .2020 ,10 (10)

(18)滕传峰. Fetotoxicity of Nanoparticles: Causes and Mechanisms .Nanomaterials .2021 (3)

(19)孙海南. Cytotoxicity-Related Bioeffects Induced by Nanoparticles: The Role of Surface Chemistry .Frontiers in Bioengineering and Biotechnology .2019 (7)

(20)李飞. Reducing Both Pgp Overexpression and Drug Efflux with Anti-Cancer Gold-Paclitaxel Nanoconjugates. .Plos one .2016 (7)

(21)董梦琦. Novel Natural Product- and Privileged Scaffold-Based Tubulin Inhibitors Targeting the Colchicine Binding Site. .Molecule .2016 (10)

(22)滕传峰. Fetotoxicity of Nanoparticles: Causes and Mechanisms .Nanomaterials .2021 ,11 (3)

(23)张贵强. Poly(ethylene glycol)-Mediated Assembly of Vaccine Particles to Improve Stability and Immunogenicity .ACS Applied Materials & Interfaces .2021 ,13 (12):13978

(24)翟淑梅. Recent Advances in Nanomedicine for the Diagnosis and Therapy of Liver Fibrosis .Nanomaterials .2020 (10)

(25)孙海南. The Rational Design and Biological Mechanisms of Nanoradiosensitizers .Nanomaterials .2020 (10)

(26)孙海南. Gold Nanoparticle-Induced Cell Death and Potential Applications in Nanomedicine .INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES .2018 (3)

(27)孙海南. Cytotoxicity-Related Bioeffects Induced by Nanoparticles: The Role of Surface Chemistry .Frontiers in Bioengineering and Biotechnology .2019 ,7

(28)翟淑梅. 生物学方法在环境内分泌干扰物检测及评价中的应用 .《环境化学》 .2008 ,27 (5):684

(29)翟淑梅. Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells .J Bio Inorg Chem .2010 ,15 (2):259

(30)贾建博. Interactions Between Nanoparticles and Dendritic Cells: From the Perspective of Cancer Immunotherapy .FRONTIERS IN ONCOLOGY .2018 ,8

(31)赵海燕. Ultrasensitive and Accurate Assay of Human Methyltransferase Activity at the Single-Cell Level Based on a Single Integrated Magnetic Microprobe .ACS Applied Materials & Interfaces .2017 ,9 (35):29554

(32)贾建博. Susceptibility of Overweight Mice to Liver Injury as a Result of the ZnO Nanoparticle-Enhanced Liver Deposition of Pb2+ .Environmental Science & Technology .2017 ,51 (3):1775

(33)闫兵. Experimental Modulation and Computational Model of Nano-Hydrophobicity. .Biomaterials .2015

(34)翟淑梅. A Novel Dithiocarbamate Analogue with Potentially Decreased ALDH Inhibition has Copper-Dependent Proteasome-Inhibitory and Apoptosis–Inducing Activity in Human Breast Cancer Cells .Cancer letters .2011 ,300 (1):87

(35)翟淑梅. Overexpression of a Zea mays phospholipase C1 gene enhances drought tolerance in tobacco in part by maintaining stability in the membrane lipid composition .Plant Cell Tissue Organ Culture .2013 ,115 (2)

(36)张秋. Anti-tumor selectivity of a novel Tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models .Biochem Pharmacol .2013 ,86 (3):351

(37)翟淑梅. overexpression of the phosphatidylinositol synthase gene from Zea mays in tobacco plants alters the membrane lipids composition and improves drought stress tolerance .planta .2012

(38)闫兵. Enhanced cancer cell killing by a targeting gold nanoconstruct with doxorubicin payload under X-ray irradiation .RSC advances .2013 ,3 :21596

(39)翟淑梅. Reducing Both Pgp Overexpression and Drug Efflux with Anti-Cancer Gold-Paclitaxel Nanoconjugates. .Plos one .2016

(40)翟淑梅. Recent Patents on Treatment of Severe Acute Respiratory Syndrome (SARS) .Recent patents on Anti-Infective Drug Discovery .2007 ,10 :1

(41)闫兵. From fighting depression to conquering tumors: a novel tricyclic thiazepine compound as a tubulin polymerization inhibitor .Cell Death & Disease .2016

(42)翟淑梅. Induction of Size-Dependent Breakdown of Blood-Milk Barrier in Lactating Mice by TiO2 Nanoparticles .Plos one .2015

(43)翟淑梅. Novel Natural Product- and Privileged Scaffold-Based Tubulin Inhibitors Targeting the Colchicine Binding Site. .Molecule .2016

(44)张秋. P-glycoprotein-evading anti-tumor activity of a novel tubulin and HSP90 dual inhibitor in a .Journal of Pharmacological Sciences .2014 ,126 (1):66

(45)张举仁. Overexpression of the phosphatidylinositol synthase gene (ZmPIS) conferring drought stress tolerance by altering membrane lipid composition and increasing ABA synthesis in maize .《Plant, Cell and Environment》 .2013

(46)闫兵. Analytical strategies for real-time,non-invasive tracking of carbon nanomaterials in vivo .Trends in Analytical Chemistry .2013

(47)张斌. Adsorption of Bisphenol A to a Carbon Nanotube Reduced Its Endocrine Disrupting Effect in Mice Male Offspring .INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES .2014 ,15 (9):15981

(48)翟淑梅. Mechanistic understanding of toxicity from nanocatalysts .INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES .2014

(49)翟淑梅. Synergistic action by multi-targeting compounds produces a potent compound combination for human NSCLC both in vitro and in vivo .Cell Death Dis. .2014

(50)闫兵. Cell Rescue by Nanosequestration: Reduced Cytotoxicity of An Environmental Remediation Residue, Mg(OH)2 Nanoflake/Cr(VI) Adduct .Environ. Sci. Technol .2014

(51)闫兵. Tuning Cell Autophagy by Diversifying Carbon Nanotube Surface Chemistry .ACS nano .2014

(52)翟淑梅. 碳纳米管毒性研究的新进展 .《环境化学》 .2008 ,27 (6):839

(53)张秋. Natural Product–Inspired Synthesis of Thiazolidine and Thiazolidinone Compounds and Their Anticancer Activities .Curr Pharm Des .2010 ,16 (16):1826

(54)闫兵. Design, Synthesis, Cytoselective Toxicity, Structure–Activity Relationships, and Pharmacophore of Thiazolidinone Derivatives Targeting Drug-Resistant Lung Cancer Cells .Journal of Medicinal Chemistry .2008 ,51 (5):1242

(55)张秋. Anti-tumor selectivity of a novel Tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models .Biochem Pharmacol .2013 ,86 (3):351

(56)闫兵. Enhanced cancer cell killing by a targeting gold nanoconstruct with doxorubicin payload under X-ray irradiation .RSC advances .2013 ,3 :21596

(57)闫兵. From fighting depression to conquering tumors: a novel tricyclic thiazepine compound as a tubulin polymerization inhibitor .《Cell Death and Disease》 .2016

(58)张秋. P-glycoprotein-evading anti-tumor activity of a novel tubulin and HSP90 dual inhibitor in a .Journal of Pharmacological Sciences .2014 ,126 (1):66

(59)张举仁. Overexpression of the phosphatidylinositol synthase gene (ZmPIS) conferring drought stress tolerance by altering membrane lipid composition and increasing ABA synthesis in maize .《Plant, Cell and Environment》 .2013

(60)张斌. Adsorption of Bisphenol A to a Carbon Nanotube Reduced Its Endocrine Disrupting Effect in Mice Male Offspring .INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES .2014 ,15 (9):15981

(61)闫兵. Cell Rescue by Nanosequestration: Reduced Cytotoxicity of An Environmental Remediation Residue, Mg(OH)2 Nanoflake/Cr(VI) Adduct .Environ. Sci. Technol .2014

(62)闫兵. Tuning Cell Autophagy by Diversifying Carbon Nanotube Surface Chemistry .ACS nano .2014

(63)张秋. Natural Product–Inspired Synthesis of Thiazolidine and Thiazolidinone Compounds and Their Anticancer Activities .Curr Pharm Des .2010 ,16 (16):1826

(64)闫兵. Design, Synthesis, Cytoselective Toxicity, Structure–Activity Relationships, and Pharmacophore of Thiazolidinone Derivatives Targeting Drug-Resistant Lung Cancer Cells .Journal of Medicinal Chemistry .2008 ,51 (5):1242

(65)张斌. Adsorption of Bisphenol A to a Carbon Nanotube Reduced Its Endocrine Disrupting Effect in Mice Male Offspring .INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES .2014 ,15 (9):15981

(66)闫兵. Cell Rescue by Nanosequestration: Reduced Cytotoxicity of An Environmental Remediation Residue, Mg(OH)2 Nanoflake/Cr(VI) Adduct .Environ. Sci. Technol .2014

(67)闫兵. Tuning Cell Autophagy by Diversifying Carbon Nanotube Surface Chemistry .ACS nano .2014

(68)贾建博. Interactions Between Nanoparticles and Dendritic Cells: From the Perspective of Cancer Immunotherapy .FRONTIERS IN ONCOLOGY .2018 ,8

(69)闫兵. Enhanced cancer cell killing by a targeting gold nanoconstruct with doxorubicin payload under X-ray irradiation .RSC advances .2013 ,3 :21596

(70)闫兵. From fighting depression to conquering tumors: a novel tricyclic thiazepine compound as a tubulin polymerization inhibitor .《Cell Death and Disease》 .2016

(71)闫兵. Design, Synthesis, Cytoselective Toxicity, Structure–Activity Relationships, and Pharmacophore of Thiazolidinone Derivatives Targeting Drug-Resistant Lung Cancer Cells .Journal of Medicinal Chemistry .2008 ,51 (5):1242

(72)赵海燕. Ultrasensitive and Accurate Assay of Human Methyltransferase Activity at the Single-Cell Level Based on a Single Integrated Magnetic Microprobe .ACS Applied Materials & Interfaces .2017 , 9 (35):29554

(73)闫兵. Experimental Modulation and Computational Model of Nano-Hydrophobicity. .Biomaterials .2015

(74)张举仁. Overexpression of the phosphatidylinositol synthase gene (ZmPIS) conferring drought stress tolerance by altering membrane lipid composition and increasing ABA synthesis in maize .《Plant, Cell and Environment》 .2013

(75)闫兵. Analytical strategies for real-time,non-invasive tracking of carbon nanomaterials in vivo .Trends in Analytical Chemistry .2013

(76)张秋. Natural Product–Inspired Synthesis of Thiazolidine and Thiazolidinone Compounds and Their Anticancer Activities .Curr Pharm Des .2010 ,16 (16):1826

(77)贾建博. Susceptibility of Overweight Mice to Liver Injury as a Result of the ZnO Nanoparticle-Enhanced Liver Deposition of Pb2+ .Environmental Science & Technology .2017 , 51 (3):1775

(78)张秋. P-glycoprotein-evading anti-tumor activity of a novel tubulin and HSP90 dual inhibitor in a .Journal of Pharmacological Sciences .2014 ,126 (1):66

(79)张秋. Anti-tumor selectivity of a novel Tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models .Biochem Pharmacol .2013 ,86 (3):351

(80)翟淑梅. A Novel Dithiocarbamate Analogue with Potentially Decreased ALDH Inhibition has Copper-Dependent Proteasome-Inhibitory and Apoptosis–Inducing Activity in Human Breast Cancer Cells .Cancer letters .2011 ,300 (1):87

(81)翟淑梅. Novel Natural Product- and Privileged Scaffold-Based Tubulin Inhibitors Targeting the Colchicine Binding Site. .Molecule .2016

(82)翟淑梅. Reducing Both Pgp Overexpression and Drug Efflux with Anti-Cancer Gold-Paclitaxel Nanoconjugates. .Plos one .2016

(83)翟淑梅. Induction of Size-Dependent Breakdown of Blood-Milk Barrier in Lactating Mice by TiO2 Nanoparticles .Plos one .2015

(84)翟淑梅. Mechanistic understanding of toxicity from nanocatalysts .INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES .2014

(85)翟淑梅. Synergistic action by multi-targeting compounds produces a potent compound combination for human NSCLC both in vitro and in vivo .Cell Death Dis. .2014

(86)翟淑梅. Overexpression of a Zea mays phospholipase C1 gene enhances drought tolerance in tobacco in part by maintaining stability in the membrane lipid composition .Plant Cell Tissue Organ Culture .2013 ,115 (2)

(87)翟淑梅. overexpression of the phosphatidylinositol synthase gene from Zea mays in tobacco plants alters the membrane lipids composition and improves drought stress tolerance .Planta .2012

(88)翟淑梅. Recent Patents on Treatment of Severe Acute Respiratory Syndrome (SARS) .Recent patents on Anti-Infective Drug Discovery .2007 ,10 :1

(89)翟淑梅. 碳纳米管毒性研究的新进展 .《环境化学》 .2008 ,27 (6):839

(90)翟淑梅. 生物学方法在环境内分泌干扰物检测及评价中的应用 .《环境化学》 .2008 ,27 (5):684

(91)翟淑梅. Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells .J Bio Inorg Chem .2010 ,15 (2):259

1. 2-苯醚基亚氨基-5-(2-羟基-苯甲基)-1,3-噻唑-4-酮在制备抗脑癌药物中的应用

2. 一种二茂铁酰胺类分子化合物修饰的金纳米颗粒在制药中的应用

3. 一种具有表面多样性的金纳米颗粒系列化合物

4. T型钙离子通道抑制剂NNC55-0396在制备抗神经退行性疾病药物中的应用

5. 一种基于碳纳米材料的空气颗粒污染物模型及其应用

6. 2-(2,2-二苯基环丙基)-4,5-二氢-1H-咪唑在制备抗神经退化性疾病药物中的应用

1. MXene基气凝胶的制备技术开发与油水分离效率分析, 2024-08-02-2025-12-31

2. 多酚基纳米颗粒的制备及其在肿瘤治疗中的应用, 2024-08-02-2025-12-31

3. 基于深度学习的OCR识别体系构建及在医疗保险中的应用研究, 2024-05-22-2024-12-31

4. 多靶点识别人工生物体系构建与优化, 2023-12-01-2028-11-30

5. （包干项目）金属-多酚网络在肿瘤疫苗递送及免疫联合治疗中的应用研究, 2022-11-01-2025-12-30

6. 荧光编码微球关键技术的研发 , 2022-02-01-2024-07-31

7. 金属离子诱导形成Pickering乳液和泡沫用于重金属工业废水污染控制, 2023-01-06-2025-12-31

8. 目标污染物/纳米材料和组装界面的表征方法及污染物去除过程中的安全性评价, 2010-01-01-2014-12-31

9. 水污染治理所用纳米材料的生物安全性, 2016-07-01-2021-06-30

10. 目标污染物/纳米材料和组装界面的表征方法及污染物去除过程中的安全性评价, 2010-01-01-2011-12-31

11. 典型纳米材料的生物毒性效应及调控研究, 2011-08-31-2016-12-31

12. 选择性治疗耐药性肿瘤的噻唑烷酮类小分子探针化合物的设计、合成及其体内外, 2010-01-01-2012-12-31

13. 转ZmNF-YB3等基因的抗旱耐盐新种质的创制与优选, 2016-01-01-2020-12-31

14. 玉米NF-Y复合体的作用机制及在抗逆育种中的应用, 2015-08-17-2019-12-31

15. 噻唑烷酮类小分子化合物选择性抗脑神经胶质瘤作用的机制研究, 2013-10-01-2016-10-31

16. ZmNF-YB3基因的转化与耐旱新材料的创制, 2013-01-01-2015-12-31

17. 环境中碳纳米管生物毒性的分子机制与调控研究, 2011-01-01-2013-12-31

18. 玉米叶发育调控基因NLS2的分离及其功能研究, 2016-10-29-2019-06-30

19. 肿瘤细胞中YIPF2调控TNFRSF10B的分子机制, 2015-08-17-2019-12-31

20. CD74调控乳腺癌细胞迁移的分子机制, 2014-08-15-2018-12-31

21. 功能化金纳米颗粒的制备及其分析, 2010-11-01-2013-11-01

22. 基于蛋白酶体为靶点的新型铜配体PDTC衍生物库的筛选及体内外抗癌活性研究, 2010-06-01-2012-12-01

23. 单一表面理化性质渐变的金纳米颗粒库对树突状细胞免疫功能的调节及机制研究, 2016-08-17-2020-12-31

24. 纳米银对非酒精性脂肪肝小鼠的肝脏毒性及相关机制的研究, 2014-12-01-2017-12-31

25. 基于蛋白酶体为靶点的新型铜配体DiS衍生物库的筛选及其抗癌活性研究, 2010-01-01-2012-12-31